Product Name: A-1155463

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CAT#: A-6045


A-1155463 Chemical Structure A-1155463 chemical structure

IUPAC/Chemical name: 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-(4-(3-(dimethylamino)prop-1-yn-1-yl)-2-fluorophenoxy)propyl)thiazole-4-carboxylic acid

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Biological Activity
A-1155463 is a highly potent and selective BCL-XL inhibitor. A-1155463 is substantially more potent against BCL-XL-dependent cell lines relative to WEHI-539, while possessing none of its inherent pharmaceutical liabilities. A-1155463 caused a mechanism-based and reversible thrombocytopenia in mice and inhibited H146 small cell lung cancer xenograft tumor growth in vivo following multiple doses. A-1155463 thus represents an excellent tool molecule for studying BCL-XL biology as well as a productive lead structure for further optimization.
Technical Data
M.Wt:      669.79
Formula:     C35H32FN5O4S2
CAS#: 1235034-55-5
Purity: >99 % by HPLC
Storage Conditions: Room temperature for short term or -20ºC for 3 years.