Product Name: A-1331852

Request A-1331852

CAT#: A-6046


  Synonym:A-1331852,

A-1331852 Chemical Structure A-1331852 chemical structure


IUPAC/Chemical name: 3-(1-(((3r,5r,7r)-adamantan-1-yl)methyl)-5-methyl-1H-pyrazol-4-yl)-6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)picolinic acid


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Biological Activity
A-1331852 is a potent and BCL-XL-selective inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML. BCL-XL-selective inhibitors have the potential to enhance the efficacy of docetaxel in solid tumors and avoid the exacerbation of neutropenia observed with navitoclax. A-1331852 may have potential as improved cancer therapeutics.
Technical Data
M.Wt:      658.8
Formula:     C38H38N6O3S
CAS#: 1430844-80-6
Purity: >99 % by HPLC
Storage Conditions: Room temperature for short term or -20ºC for 3 years.

Reference