Product Name: ABC294640

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CAT#: A-1269


  Synonym:ABC294640,ABC-294640

ABC294640 Chemical Structure ABC294640 chemical structure


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IUPAC/Chemical name: (1s,3r,5R,7S)-3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide

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Biological Activity
ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis and may result in an inhibition of cell proliferation in cancer cells overexpressing SK2. SK2 and its isoenzyme SK1 are overexpressed in numerous cancer cell types. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Technical Data
CAS#: 915385-81-8
Chemical Formula: C23H25ClN2O
Exact Mass: 380.16554
Molecular Weight: 380.91040
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.

Reference