Product Name: ABL-001
 CAT#: A-1967

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ABL-001 Chemical Structure
ABL-001chemical structure

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IUPAC/Chemical name:(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide

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Biological Activity
An orally bioavailable, allosteric Bcr-Abl tyrosine kinase inhibitor with potential antineoplastic activity. Designed to overcome resistance, ABL001 binds to the Abl portion of the Bcr-Abl fusion protein at a location that is distinct from the ATP-binding domain. This binding results in the inhibition of Bcr-Abl-mediated proliferation and enhanced apoptosis of Philadelphia chromosome-positive (Ph+) hematological malignancies.
Technical Data

Purity: >98% by HPLC
CAS#:1492952-76-7
Chemical Formula:C20H18CIF2N5O3
Molecular Weight:449.84
Storage Conditions: 2ºC to 8 ºC for short term, or -20ºC for 3 years.

IUPAC/Chemical name:(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5-(1H-pyrazol- 5-yl)nicotinamide
Canonical SMILES:
Reference





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