Product Name: ABT-494

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CAT#: A-6104


  Synonym:ABT-494,

ABT-494 Chemical Structure ABT-494 chemical structure


IUPAC/Chemical name: (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide


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Biological Activity
Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling.
Technical Data
M.Wt:      380.3752
Formula:     C17H19F3N6O
CAS#: 1310726-60-3
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.

Reference