Product Name: AC-710
 CAT#: A-1972

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 Synonym: ,

AC-710 Chemical Structure
AC-710chemical structure

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IUPAC/Chemical name:

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Biological Activity
AC710 is a potent, orally active, and selective platelet-derived growth factor receptor-family kinase inhibitor with potential anticancer activity. Its IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα.. AC710 causes tumor regression of leukemia cell xenografts in mice. AC710 also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. AC710 is now a preclinical development candidate.
Technical Data

Purity: >99%
CAS#:1351522-04-7
Chemical Formula:C31H42N6O4
Molecular Weight:562.7
AC-710 MSDSAC-710 CoA

IUPAC/Chemical name:N-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-5-((1-ethyl-2,2,6,6-tetramethylpiperidin-4-yl)oxy)picolinamide
Canonical SMILES:O=C(NC1=CC=C(NC(NC2=NOC(C(C)(C)C)=C2)=O)C=C1)C3=NC=C(OC4CC(C)(C)N(CC)C(C)(C)C4)C=C3
Reference





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