Product Name: ACP-196 (Acalabrutinib)
 CAT#: A-1968

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 Synonym:ACP-196 (Acalabrutinib) ,

ACP-196 (Acalabrutinib) Chemical Structure
ACP-196 (Acalabrutinib)chemical structure

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Biological Activity
Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival
Technical Data

Purity: >99%
CAS#:1420477-60-6
Chemical Formula:C26H23N7O2
Molecular Weight:465.52
ACP-196 (Acalabrutinib) MSDSACP-196 (Acalabrutinib) CoA

IUPAC/Chemical name:(S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide
Canonical SMILES:O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2
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