Product Name: AG-221

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CAT#: A-1324


  Synonym:AG-221,

AG-221 Chemical Structure AG-221 chemical structure


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Biological Activity
AG-221 is an IDH2 ( isocitrate dehydrogenase) inhibitor. IDH2 inhibitors block the catalytic activity of the mitochondrial isoform of isocitrate dehydrogenase. Mutated IDH is associated with a change in metabolite flux, including accumulation of 2-hydroxyglutarate (2-HG) in some types of cancer cells. The presence of 2-HG may prevent cell differentiation and promote transformation of cancerous cells.
Technical Data
Purity: >99%
M.Wt:      473.4
Formula:     C19H17F6N7O
CAS#: 1446502-11-9
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.

Reference