AG-221 is an IDH2 ( isocitrate dehydrogenase) inhibitor. IDH2 inhibitors block the catalytic activity of the mitochondrial isoform of isocitrate dehydrogenase. Mutated IDH is associated with a change in metabolite flux, including accumulation of 2-hydroxyglutarate (2-HG) in some types of cancer cells. The presence of 2-HG may prevent cell differentiation and promote transformation of cancerous cells.
2ºC to 8 ºC, or -20ºC for 3 years.