99% by HPLC - Purity whole section PUT image in userfiles/ and Storage condition at bottom, ADD pricing to price3.xml in PRODUCTS folder> AG-881(> 99% by HPLC )|Supplier|Active Biochem

Product Name: AG-881

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CAT#: A-6078


  Synonym:AG-881,

AG-881 Chemical Structure AG-881 chemical structure


IUPAC/Chemical name: (6-(6-chloro-2-pyridinyl)-N2,N4-bis[(1R)-2,2,2-trifluoro-1-methylethyl]- 1,3,5-Triazine-2,4-diamine


Price of AG-881

We offer a substantial discount on larger orders,
please inquire via salesusa@activebiochem.com
sales@activebiochem.com or 1-800-857-0985 (USA Toll Free#) Fax: 1-201-884-1288 (USA Fax#)


Biological Activity
AG-881 is a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP+], mitochondrial) in the mitochondria, with potential antineoplastic activity. AG-881 specifically inhibits mutant forms of IDH1 and IDH2, thereby inhibiting the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated signaling and leads to both an induction of cellular differentiation and an inhibition of cellular proliferation in tumor cells expressing IDH mutations
Technical Data
M.Wt:      414.74
Formula:     C14H13ClF6N6
CAS#: 1644545-52-7
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.

Reference