Product Name: AMG-176

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CAT#: A-6056


AMG-176 Chemical Structure AMG-176 chemical structure

IUPAC/Chemical name:

Price of AMG-176

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Biological Activity
AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (myeloid cell leukemia-1), with potential pro-apoptotic and antineoplastic activities. Upon administration, AMG 176 binds to and inhibits the activity of MCL-1. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells. MCL-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.
Technical Data
M.Wt:      613.21
Formula:     C33H41ClN2O5S
CAS#: 1883727-34-1
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.