Product Name: ARN-509

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CAT#: A-6036


  Synonym:ARN-509, Apalutamide, JNJ56021927, JNJ-56021927

ARN-509 Chemical Structure ARN-509 chemical structure


IUPAC/Chemical name: 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide


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Biological Activity
Apalutamide, also known as ARN-509 and JNJ-56021927 , is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells.
Technical Data
M.Wt:      477.43
Formula:     C21H15F4N5O2S
CAS#: 956104-40-8
Purity: >99 % by HPLC
Storage Conditions: Room Temperature for short term or -20ºC for 3 years.

Reference