Product Name: ARQ-087

Request ARQ-087

CAT#: A-6001


  Synonym:ARQ-087,

ARQ-087 Chemical Structure ARQ-087 chemical structure


IUPAC/Chemical name: (6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine


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Biological Activity
An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor ARQ 087 binds to and potently inhibits the activity of FGFR subtypes 1, 2 and 3. This may result in the inhibition of FGFR-mediated signal transduction pathways, tumor cell proliferation, tumor angiogenesis and tumor cell death in FGFR-overexpressing tumor cells. FGFR, a receptor tyrosine kinase, is upregulated in many tumor cell types and plays a key role in tumor cellular proliferation, differentiation, angiogenesis and survival.
Technical Data
M.Wt:      468.57
Formula:     C29H29FN4O
CAS#: 1234356-69-4
Purity: >99% by HPLC
Storage Conditions: 0ºC to 4 ºC for short term or -20ºC for 3 years.

Reference