Product Name: ARQ-087

Request ARQ-087

CAT#: A-6001


ARQ-087 Chemical Structure ARQ-087 chemical structure

IUPAC/Chemical name: (6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine

Price of ARQ-087

We offer a substantial discount on larger orders,
please inquire via or Fax: 1-201-884-1288 (USA Fax#)

Biological Activity
An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor ARQ 087 binds to and potently inhibits the activity of FGFR subtypes 1, 2 and 3. This may result in the inhibition of FGFR-mediated signal transduction pathways, tumor cell proliferation, tumor angiogenesis and tumor cell death in FGFR-overexpressing tumor cells. FGFR, a receptor tyrosine kinase, is upregulated in many tumor cell types and plays a key role in tumor cellular proliferation, differentiation, angiogenesis and survival.
Technical Data
M.Wt:      468.57
Formula:     C29H29FN4O
CAS#: 1234356-69-4
Purity: >99% by HPLC
Storage Conditions: 0ºC to 4 ºC for short term or -20ºC for 3 years.