Product Name: ARQ-197(Tivantinib) Request ARQ-197
ARQ-197 Chemical Structure
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ARQ197(ARQ-197) is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. Tivantinib binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing consitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.
Soluble in DMSO
Optical purity: 100% by chiral HPLC
>99% by HPLC
Storage Conditions :
Room temperature, or -20ºC for 2 year. Protect from light.
1. ARQ-197, an oral small-molecule inhibitor of c-Met for the treatment of solid tumors.
Bagai R, Fan W, Ma PC.
IDrugs. 2010 Jun;13(6):404-14.
PMID: 20506063 [PubMed - indexed for MEDLINE]
2. ARQ 197, a Novel and Selective Inhibitor of the Human c-Met Receptor Tyrosine Kinase with Antitumor Activity
N Munshi, S Jeay, Y Li, CR Chen- Molecular cancer, 2010 - AACR
3.[CITATION] Results from ARQ 197
C209: a global randomized placebo-controlled phase II clinical trial of erlotinib plus ARQ 197
versus erlotinib plus placebo in
JH Schiller, WL Akerley, W Brugger, D Ferrari - J Clin Oncol, 2010
Purchase(buy) c-Met inhibitor ARQ-197 at Active Biochem and the United State(U.S.), Germany, Japan, France,United Kingdom(UK),Switzerland, Australia distributors.