Product Name: ARRY-543
 CAT#: A-1373

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 Synonym:ARRY-543,

ARRY-543 Chemical Structure
ARRY-543/I-BET-726 chemical structure


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Biological Activity
Varlitinib, also known as ARRY-543, is an orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types. Due to the dual inhibition of both EGFR and Her-2, this agent may be therapeutically more effective than agents that inhibit EGFR or Her-2 alone.
Technical Data

Mol. Formula: C22H19ClN6O2 S
MW: 466.94
CAS#: 845272-21-1
Purity: >99%
Chiral Purity: 100%
ARRY-543 MSDS ARRY-543 CoA

Reference







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