Product Name: AVL-292
Synonym:CC-292; AVL292; AVL-292; AVL 292
AVL-292 Chemical Structure
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AVL-292, also known as CC-292, is an orally bioavailable, selective inhibitor of Bruton’s agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, AVL-292 targets and covalently binds to BTK, thereby preventing its activity. By irreversibly inhibiting BTK, administration of this agent may lead to an inhibition of B cell receptor (BCR) signaling and may inhibit cell proliferation of B-cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.
Mol. Formula: C22H22FN5O3
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
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