Product Name: AVL-292
 CAT#: A-1299

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 Synonym:CC-292; AVL292; AVL-292; AVL 292

AVL-292 Chemical Structure
AVL-292 chemical structure


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IUPAC/Chemical name: N-(3-((5-fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

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Biological Activity
AVL-292, also known as CC-292, is an orally bioavailable, selective inhibitor of Bruton’s agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, AVL-292 targets and covalently binds to BTK, thereby preventing its activity. By irreversibly inhibiting BTK, administration of this agent may lead to an inhibition of B cell receptor (BCR) signaling and may inhibit cell proliferation of B-cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.
Technical Data

Mol. Formula: C22H22FN5O3
MW: 423.17
CAS#: 1202757-89-8
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
AVL-292 MSDS AVL-292 CoA

Reference







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