Product Name: AZ-628

Request AZ-628

CAT#: A-9011


  Synonym:AZ-628

AZ-628 Chemical Structure
AZ-628 chemical structure


5 stars, based on 5755 reviews
IUPAC/Chemical name:

Price of AZ-628

We offer a substantial discount on larger orders,
please inquire via sales@activebiochem.com
or Fax: 1-201-884-1288 (USA Fax#)


Biological Activity
AZ-628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.
Potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). Displays selectivity for Raf kinases over a panel of 150 other kinases; inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Also inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.
Technical Data
Chemical Formula: C27H25N5O2
M.Wt: 451.52
CAS: 878739-06-1
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.

Reference




Purchase(buy) AZ-628 at Active Biochem and the United State(U.S.), Germany, Japan, France,United Kingdom(UK),Switzerland, Australia distributors.