Product Name: AZD-0156

Request AZD-0156

CAT#: A-6008


  Synonym:AZD-0156,

AZD-0156 Chemical Structure AZD-0156 chemical structure


IUPAC/Chemical name: 8-[6-[3-(dimethylamino)propoxy]-3-pyridyl]-3-methyl-1-tetrahydropyran-4-yl-imidazo[4,5-c]quinolin-2-one


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Biological Activity
An orally bioavailable ataxia telangiectasia mutated (ATM) kinase inhibitor, with potential chemo-/radio-sensitizing and antineoplastic activities. Upon oral administration, AZD0156 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. In addition, AZD0156 sensitizes tumor cells to chemo- and radiotherapy. ATM, a serine/threonine protein kinase, is upregulated in a variety of cancer cell types; it is activated in response to DNA damage and plays a key role in DNA-strand repair.
Technical Data
M.Wt:      461.56
Formula:     C26H31N5O3
Purity: >98% by HPLC
CAS#: 1821428-35-6
Storage Conditions: 0ºC to 4 ºC for short term, or -20ºC for 3 years.

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