Product Name: AZD-3759
 CAT#: A-1395

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 Synonym:AZD-3759 ,

AZD-3759 Chemical Structure
AZD-3759chemical structure

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IUPAC/Chemical name:

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IUPAC/Chemical name: (R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate
Canonical SMILES: O=C(N1[C@H](C)CN(C)CC1)OC2=CC3=C(NC4=CC=CC(Cl)=C4F)N=CN=C3C=C2OC
Biological Activity
Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors, AZD3759 or AZD9291, in Patients Who Have Advanced Non-Small Cell Lung Cancer.
AZD-3759 is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR-mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR-overexpressing cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. Check for active clinical trials using this agent.
Technical Data

Purity: >99%
CAS#: 1626387-80-1
Chemical Formula: C22H23ClFN5O3
Molecular Weight: 459.91
AZD-3759 MSDS AZD-3759 CoA


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