AZD-6244(ARRY-142886, Selumetinib)Request AZD-6244
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AZD-6244 (ARRY-142886) is an orally active, highly specific inhibitor of MEK that has shown tumor-suppressive activity in a wide range of preclinical models of human cancer. AZD-6244 is currently in phase II development for the treatment of melanoma, non-small cell lung and pancreatic cancer.ARRY-142886 is a potent and selective MEK1/2 inhibitor that is highly active in both in vitro and in vivo tumor models. This compound is currently being investigated in clinical studies.
ReferenceTC Yeh et al. Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor. Clin. Cancer Res. 2007, 13, 1576-1583. http://clincancerres.aacrjournals.org/content/13/5/1576.abstract