Product Name:

AZD-6244(ARRY-142886, Selumetinib)

Request AZD-6244
CAT#: A-1007    

Chemical Structure

Price of AZD-6244(ARRY-142886, Selumetinib)


We offer a substantial discount on larger orders,
please inquire via sales@activebiochem.com
or Fax: 1-201-884-1288 (USA Fax#)

We match the lowest price on market.

Biological Activity

AZD-6244 (ARRY-142886) is an orally active, highly specific inhibitor of MEK that has shown tumor-suppressive activity in a wide range of preclinical models of human cancer. AZD-6244 is currently in phase II development for the treatment of melanoma, non-small cell lung and pancreatic cancer.ARRY-142886 is a potent and selective MEK1/2 inhibitor that is highly active in both in vitro and in vivo tumor models. This compound is currently being investigated in clinical studies.

Technical Data

M.Wt: 457.7
Formula: C17H15BrClFN4O3
Purity: >99%
Storage Conditions : Room temperature, or -20ºC for 2 year.

AZD-6244 MSDS AZD-6244 CoA
Reference
TC Yeh et al. Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor. Clin. Cancer Res. 2007, 13, 1576-1583. http://clincancerres.aacrjournals.org/content/13/5/1576.abstract