Product Name:  AZD-8186  Request AZD-8186
CAT#: A-1610    

Chemical Structure
AZD-8186 chemical structure

Price of AZD-8186


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Biological Activity

AZD-8186 is a novel potent small molecule that targets the lipid kinase PI3Kβ with selectivity vs PI3Kα. AZD8186 reduces pAKT-S473 in the PTEN deficient MDA-MB-468 cell line with an IC50 <5nM, while in the PI3Kα-dependent PIK3CA mutant line BT474 it is 200 fold less potent. AZD8186 also demonstrates cellular activity versus PI3Kβ, inhibiting IgM-dependent pAKT-S473 with an IC50 of 15nM.
Technical Data

Formula:C24H25F2N3O4
M.Wt:457.47
CAS#:1296270-45-5
Solubility:Soluble in DMSO
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
Reference