Product Name: AZD-8835

Request AZD-8835

CAT#: A-1517


AZD-8835 Chemical Structure
AZD-8835 chemical structure

5 stars, based on 55 reviews
IUPAC/Chemical name:

Price of AZD-8835

We offer a substantial discount on larger orders,
please inquire via
or Fax: 1-201-884-1288 (USA Fax#)

Biological Activity
AZD8835 is an inhibitor of PI3K alpha and PI3K delta.
An orally bioavailable inhibitor of the class I phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) catalytic subunit alpha (PIK3CA), with potential antineoplastic activity. PI3K alpha inhibitor AZD8835 selectively binds to and inhibits PIK3CA and its mutated forms, in the PI3K/Akt (protein kinase B)/mammalian target of rapamycin (mTOR) pathway. This results in both apoptosis and growth inhibition in PIK3CA-expressing tumor cells. By specifically targeting PIK3CA, this agent may be more efficacious and less toxic than pan-PI3K inhibitors. Dysregulation of the PI3K/Akt/mTOR pathway is often found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to chemo- and radio-therapy. PIK3CA, one of the most frequently mutated oncogenes, encodes the p110-alpha catalytic subunit of the class I PI3K.
Technical Data
Solubility: DMSO
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.


Purchase(buy) AZD-8835 at Active Biochem and the United State(U.S.), Germany, Japan, France,United Kingdom(UK),Switzerland, Australia distributors.