Product Name: Barasertib (AZD1152-HQPA)
 CAT#: A-1377

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 Synonym:AZD1152-HQPA,

AZD1152-HQPA Chemical Structure
AZD1152-HQPA/I-BET-726 chemical structure


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Biological Activity
AZD1152-HQPA (Barasertib) is a highly potent and selective Aurora B inhibitor with a Ki of 0.36 nM. AZD1152-HQPA (Barasertib) inhibits Aurora A with a Ki of 1.37 nM. AZD1152 is converted rapidly to the active AZD1152-HQPA (Barasertib) in plasma. AZD1152-HQPA (Barasertib) has a high specificity versus a panel of 50 other kinases. Consistent with inhibition of Aurora B kinase, addition of AZD1152-HQPA (Barasertib) to tumor cells in vitro induces chromosome misalignment, prevents cell division, and consequently reduces cell viability and induces apoptosis.
Technical Data

Mol. Formula: C26H30F3N7O3
MW: 507.56
CAS#: 722544-51-6
Purity: >99%
Chiral Purity: 100%
Barasertib MSDS Barasertib CoA

Reference







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