Product Name: BAY-1161909

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CAT#: A-6095


BAY-1161909 Chemical Structure BAY-1161909 chemical structure

IUPAC/Chemical name: (R)-2-(4-fluorophenyl)-N-(4-(2-((2-methoxy-4-(methylsulfonyl)phenyl)amino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)propanamide

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Biological Activity
Empesertib, also known as BAY1161909, is an orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase, with potential antineoplastic activity. Upon administration, the Mps1 kinase inhibitor BAY1161909 binds to and inhibits the activity of Mps1. This causes inactivation of the spindle assembly checkpoint (SAC), accelerated mitosis, chromosomal misalignment, chromosomal missegregation, mitotic checkpoint complex destabilization, and increased aneuploidy. This leads to the induction of cell death in cancer cells overexpressing Mps1.
Technical Data
M.Wt:      559.6164
Formula:     C29H26FN5O4S
CAS#: 1443763-60-7
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.