Product Name: BAY-1251152

Request BAY-1251152

CAT#: A-6085


  Synonym:BAY-1251152,

BAY-1251152 Chemical Structure BAY-1251152 chemical structure


IUPAC/Chemical name:


Price of BAY-1251152

We offer a substantial discount on larger orders,
please inquire via salesusa@activebiochem.com
sales@activebiochem.com or 1-800-857-0985 (USA Toll Free#) Fax: 1-201-884-1288 (USA Fax#)


Biological Activity
BAY-1251152 is a potent inhibitor of CDK9 and PTEF-b with potential antineoplastic activity. Upon administration, BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. This may cause cell cycle arrest and induce apoptosis, which may lead to a reduction in tumor cell proliferation. The protein complex PTEF-b, a heterodimer consisting of CDK9 and a regulatory cyclin subunit of the T family, is over-activated in various tumor cell types; it plays a key role in the regulation of Pol II-mediated transcription of anti-apoptotic proteins. Tumor cells are dependent on anti-apoptotic proteins for their survival.
Technical Data
M.Wt:     
Formula:    
CAS#:
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.

Reference