Product Name: BGB-283

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CAT#: A-6002


BGB-283 Chemical Structure BGB-283 chemical structure

IUPAC/Chemical name: rel-5-[[(1R,1aS,6bR)-1a,6b-dihydro-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1H-cyclopropa[b]benzofuran-5-yl]oxy]-3,4-

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Biological Activity
An inhibitor of the serine/threonine protein kinase B-raf (BRAF) and epidermal growth factor receptor (EGFR), with potential antineoplastic activity. BRAF/EGFR inhibitor BGB-283 selectively binds to and inhibits the activity of BRAF and certain BRAF mutant forms, and EGFR. This prevents BRAF- and EGFR-mediated signaling and inhibits the proliferation of tumor cells that either contain a mutated BRAF gene or express over-activated EGFR. In addition, BGB-283 inhibits mutant forms of the Ras proteins K-RAS and N-RAS. BRAF and EGFR are mutated or upregulated in many tumor cell types. Check for active clinical trials using this agent.
Technical Data
M.Wt:      478.42
Formula:     C25H17F3N4O3
CAS#: 1446090-77-2
Purity: >99% by HPLC
Storage Conditions: 0ºC to 4 ºC for short term or -20ºC for 3 years..