Product Name:

BI-6727

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CAT#: A-1187    

Chemical Structure

BI6727,BI-6727
IUPAC/Chemical name:
N-((1s,4S)-4-(4-(cyclopropylmethyl)piperazin-1-yl)cyclohexyl)-4-(((R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxybenzamide

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Biological Activity

BI6727 is a dihydropteridinone Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity.
BI 6727 is a highly potent (enzyme IC(50) = 0.87 nmol/L, EC(50) = 11-37 nmol/L on a panel of cancer cell lines) and selective dihydropteridinone with distinct properties.
Technical Data

Formula: C34H50N8O3
M.Wt: 618.81
CAS No.: 755038-65-4
Solubility: DMSO
Optical purity: 100% by chiral HPLC
Chemical Purity: >99% by HPLC
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 2 years.
BI-6727 MSDS BI-6727 CoA
Reference