Afatinib (BIBW-2992)Request Afatinib (BIBW-2992)
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Afatinib (BIBW-2992)is an irreversible, potent, orally bioavailable inhibitor of EGFR and HER2 with IC50's of 0.5 nM and 14 nM, respectively. BIBW-2992 is a second generation of tyrosine kinase inhibitor (TKI). BIBW-2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those not sensitive to these standard therapies. BIBW-2992 (Tovok) overcomes resistance of Tarceva in clinic.
Optical purity: 100% by chiral HPLC
Chemical Purity: >99% by HPLC
Storage Conditions :Room temperature, or -20ºC for 2 year.
BIBW-2992 MSDS BIBW-2992 CoA