Product Name:

BKM-120

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CAT#: A-1108    

Chemical Structure

Price of BKM-120


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Biological Activity

BKM-120 is a PI3K inhibitor in clinical trials.
Technical Data

Formula:C18H21F3N6O2
M.Wt:410.39
CAS#:944396-07-0
Purity:>99%
Synonyms:5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine
Storage Conditions :Room temperature, or -20ºC for 2 year.
BKM-120 MSDS BKM-120 CoA
Reference
[CITATION] NVP-BKM120, a pan class I PI3K inhibitor impairs microvascular permeability and tumor growth as detected by DCE-MRI and IFP measurements via radio ˇ­
CR Schnell, S Arnal, M Becket - 101st American Association for Cancer Research ˇ­, 2010

Targeting phosphatidylinositol 3 kinase (PI3K)-Akt beyond rapalogs
S Ogita, P LoRusso - Targeted Oncology, 2011 - Springer
... More specific PI3K inhibitors BKM 120 is a specific PI3K inhibitor [87]. Its antitumor activity was observed initially in a xenograft model of Targ Oncol Page 6. ... Only one colorectal patient in the study carried PIK3CA mutation and did not respond to the BKM120 compound. ...

Status of PI3K inhibition and biomarker development in cancer therapeutics
B Markman, F Atzori, J Perez-Garciaˇ­ - Annals of ˇ­, 2010 - Eur Soc Med Oncology
... NVP-BGT226 is the second PI3K inhibitor from Novartis to have entered clinical trials, having enrolled the first patient into a dose escalation trial in early 2008. NVP-BKM120, also from Novartis, commenced phase I clinical development in late 2008. ...