Product Name: BLU-9931

Request BLU-9931

CAT#: A-6080


  Synonym:BLU-9931,

BLU-9931 Chemical Structure BLU-9931 chemical structure


IUPAC/Chemical name: N-(2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide


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Biological Activity
BLU9931 is a potent and irreversible small-molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor xenograft that overexpresses FGF19 mRNA but lacks FGF19 amplification. Approximately one third of patients with HCC whose tumors express FGF19 together with FGFR4 and its coreceptor klotho β (KLB) could potentially respond to treatment with an FGFR4 inhibitor.
Technical Data
M.Wt:      509.38
Formula:     C26H22Cl2N4O3
CAS#: 1538604-68-0
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.

Reference