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Inhibitor of the IGF-IR (IC50 = 100 nM), high human serum protein binding (99.6%), and oral exposure (50.9 mM h). Treatment of the IGF1R-Sal cells with BMS-536924 resulted in a dose-dependent inhibition of proliferation, with an IC50 of 0.11 Amol/L. MCF7 cells were also significantly inhibited (IC50 = 0.46 Amol/L). A different breast tumor cell line, BT474 was relatively insensitive to the compound, with an IC50 that is >10 fold higher than that for the IGF1R-Sal cells. ATP competitive inhibitor, IGF1R and IR dual kinase inhibitor