Product Name: BMS-833923(XL-139)

Request BMS-833923

CAT#: A-1700


  Synonym:BMS-833923, XL-139

BMS-833923 Chemical Structure
BMS-833923 chemical structure


5 stars, based on 5755 reviews
IUPAC/Chemical name:

Price of BMS-833923

We offer a substantial discount on larger orders,
please inquire via sales@activebiochem.com
or Fax: 1-201-884-1288 (USA Fax#)


Biological Activity
BMS-833923 (or XL-139) is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway. SMO is a G-protein coupled receptor that lies just downstream of the SHH ligand cell surface receptor Patched-1 in the SHH pathway; in the absence of ligand Patched-1 inhibits SMO and ligand binding to Patched-1 results in increased levels of SMO. The SHH signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers.
Technical Data
Chemical Formula: C30H27N5O
M.Wt: 473.57
CAS: 1059734-66-5
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.

Reference




Purchase(buy) BMS-833923(XL-139) at Active Biochem and the United State(U.S.), Germany, Japan, France,United Kingdom(UK),Switzerland, Australia distributors.