Product Name: BMS-863233.HCl
 CAT#: A-1072

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 Synonym:BMS-863233.HCl, XL-413

BMS-863233.HCl Chemical Structure
BMS-863233.HCl chemical structure


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IUPAC/Chemical name: (S)-8-chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride

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Biological Activity
BMS-863233.HCl (also called XL-413) is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor BMS-863233.HCl binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication.
Technical Data

Mol. Formula: C14H13Cl2N3O22HCl
MW: 326.17792
CAS#: 1169562-71-3
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
BMS-863233.HCl MSDS BMS-863233.HCl CoA

Reference







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