Product Name: BVD-523
 CAT#: A-1378

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 Synonym:

BVD-523 Chemical Structure
BVD-523 chemical structure


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Biological Activity
ERK inhibitor BVD-523 An orally available inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.
Technical Data

Solubility:Soluble in DMSO
Purity: >99%
Storage Conditions: Room temperature, or -20ºC for 3 years.

Reference







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