Bortezomib( Purity > 99% by HPLC)

Product Name: Bortezomib
 CAT#: A-1014

Request Bortezomib
 Synonym: PS-341. US brand name: VELCADE. Code names: LDP 341; MLN341. ,

Bortezomib Chemical Structure
Bortezomibchemical structure

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IUPAC/Chemical name:

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Biological Activity
Bortezomib is a dipeptide boronic acid analogue with antineoplastic activity. Bortezomib reversibly inhibits the 26S proteasome, a large protease complex that degrades ubiquinated proteins. By blocking the targeted proteolysis normally performed by the proteasome, bortezomib disrupts various cell signaling pathways, leading to cell cycle arrest, apoptosis, and inhibition of angiogenesis. Specifically, the agent inhibits nuclear factor (NF)-kappaB, a protein that is constitutively activated in some cancers, thereby interfering with NF-kappaB-mediated cell survival, tumor growth, and angiogenesis. In vivo, bortezomib delays tumor growth and enhances the cytotoxic effects of radiation and chemotherapy
Technical Data

Purity: >99%
CAS#:179324-69-7
Chemical Formula:C19H25BN4O4
Molecular Weight:384.24
Bortezomib MSDSBortezomib CoA

IUPAC/Chemical name:((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid
Canonical SMILES:
Reference





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