Product Name: CFI-400945 [Free Base]

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CAT#: A-6005


  Synonym:CFI-400945 [Free Base],

CFI-400945 [Free Base] Chemical Structure CFI-400945 [Free Base] chemical structure


IUPAC/Chemical name: (1R,2S)-2-[3-[(1E)-2-[4-[[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl]phenyl]ethenyl]-1H-indazol-6-yl]-5'-methoxy-Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one


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Biological Activity
CFI-400945 is a polo-like kinase 4 (PLK4) inhibitor with potential antineoplastic activity. Upon oral administration, polo-like kinase 4 inhibitor CFI-400945 selectively inhibits PLK4, which results in the disruption of mitosis and the induction of apoptosis. PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells. PLK4, a member of the polo family of serine/threonine kinases overexpressed in a variety of cancer cell types, plays a crucial role in the regulation of centriole duplication during the cell cycle.
Technical Data

M.Wt:      534.64806
Formula:     C33H34N4O3
CAS#: 1338806-73-7
Purity: >99%
Storage Conditions: 0ºC to 4 ºC for short term or -20ºC for 3 years.

Reference