Product Name: CGM-097(NVP-CGM-097)
 CAT#: A-1315

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 Synonym:

CGM-097 Chemical Structure
CGM-097 chemical structure


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Biological Activity
CGM-097 is a potent and selective MDM2 inhibitor.
An orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.
Technical Data

Formula:C38H47ClN4O4
M.Wt:659.28
Solubility:Soluble in DMSO
Purity: >99%
Storage Conditions: Room temperature, or -20ºC for 3 years.

Reference







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