Product Name: CGM-097(NVP-CGM-097)
CGM-097 Chemical Structure
5 stars, based on 86 reviews
In stock! Order now!
Price of CGM-097
We offer a substantial discount on larger orders,
please inquire via email@example.com
or Fax: 1-201-884-1288 (USA Fax#)
CGM-097 is a potent and selective MDM2 inhibitor.
An orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.
Solubility:Soluble in DMSO
Storage Conditions: Room temperature, or -20ºC for 3 years.
Purchase(buy) CGM-097 at Active Biochem
and the United State(U.S.), Germany, Japan, France,United Kingdom(UK),Switzerland, Australia distributors.