CHS-828(GMX-1778)( Purity > 99% by HPLC)

Product Name: CHS-828(GMX-1778)
 CAT#: A-1954

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 Synonym:CHS 828; CHS828; CHS-828; GMX-1778; GMX1778; GMX 1778 ,

CHS-828(GMX-1778) Chemical Structure
CHS-828(GMX-1778)chemical structure

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IUPAC/Chemical name:

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Biological Activity
CHS-828, also known as GMX-1778, is a potent and selective NAMPT inhibitor. CHS-828 inhibits cellular synthesis of NAD. CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome. CHS 828 has shown promising anticancer activity in experimental tumor models and primary cultures of cancer cells from patients. CHS 828 showed a synergistic effect with melphalan in 67%, doxorubicin in 47%, etoposide in 38% and Ara-C in 14% of AML samples.
Technical Data

Purity: >99%
CAS#:200484-11-3
Chemical Formula:C19H22ClN5O
Molecular Weight:371.86
CHS-828(GMX-1778) MSDSCHS-828(GMX-1778) CoA

IUPAC/Chemical name:(E)-1-(6-(4-chlorophenoxy)hexyl)-2-cyano-3-(pyridin-4-yl)guanidine
Canonical SMILES:
Reference





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