Product Name: CHS-828(GMX-1778)Request CHS-828(GMX-1778)
Synonym:CHS 828; CHS828; CHS-828; GMX-1778; GMX1778; GMX 1778 ,
CHS-828(GMX-1778) Chemical Structure
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Biological ActivityCHS-828, also known as GMX-1778, is a potent and selective NAMPT inhibitor. CHS-828 inhibits cellular synthesis of NAD. CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome. CHS 828 has shown promising anticancer activity in experimental tumor models and primary cultures of cancer cells from patients. CHS 828 showed a synergistic effect with melphalan in 67%, doxorubicin in 47%, etoposide in 38% and Ara-C in 14% of AML samples.
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