Product Name:  Lucitanib(E-3810)  Request E-3810
CAT#: A-1268    

Chemical Structure

E-3810 chemical structure

Price of E-3810


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Biological Activity

Lucitanib, also known as E-3810, is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. VEGFR/FGFR dual kinase inhibitor E-3810 inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types. E-3810 is a potent dual inhibitor of VEGFR and FGFR.
Technical Data

Formula:C26H25N3O4
CAS#:1058137-23-7
M.Wt:443.49
Solubility:Soluble in DMSO
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
Reference