Product Name: E-7090

Request E-7090

CAT#: A-6063


  Synonym:E-7090,

E-7090 Chemical Structure E-7090 chemical structure


IUPAC/Chemical name: 5-((2-(4-(1-(2-hydroxyethyl)piperidin-4-yl)benzamido)pyridin-4-yl)oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide


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Biological Activity
E-7090 is a selective inhibitor of the tyrosine kinase activities of FGFR1, -2, and -3, and it is potentially for the treatment of solid tumors. In kinetic analyses of the interaction between E7090 and FGFR1 tyrosine kinase, E7090 associated more rapidly with FGFR1 than did the type II FGFR1 inhibitor ponatinib, and E7090 dissociated more slowly from FGFR1, with a relatively longer residence time, than did the type I FGFR1 inhibitor AZD4547, suggesting that its kinetics are more similar to the type V inhibitors, such as lenvatinib.
Technical Data
M.Wt:      587.677
Formula:     C32H37N5O6
CAS#: 1622204-21-0
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.

Reference