Product Name:  E-7449  Request E-7449
CAT#: A-1358    

Chemical Structure
LY2157299 chemical structure

Price of E-7449


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Biological Activity

E-7449 An orally available small molecule inhibitor of the nuclear enzymes poly (ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, E7449 selectively binds to PARP 1 and 2, thereby preventing the repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of single and double strand DNA breaks and promotes genomic instability eventually leading to apoptosis. PARP 1/2 inhibitor E7449 may enhance the cytotoxicity of DNA-damaging agents and of radiotherapy. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA.
Technical Data

Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
Reference








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