Product Name:  EPZ-004777  Request EPZ-004777
CAT#: A-1801    

Chemical Structure
EPZ-004777 chemical structure

Price of EPZ-004777


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Biological Activity

EPZ004777 is a potent, selective inhibitor of DOT1L. Exposure of leukemic cells to EPZ004777 results in selective killing of those cells bearing the MLL gene translocation, with little effect on non-MLL-translocated cells. Treatment of mixed lineage leukemia (MLL) cells with EPZ004777 selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes. In vivo administration of EPZ004777 leads to extension of survival in a mouse MLL xenograft model.
Technical Data

Formula:C28H41N7O4
M.Wt:539.68
CAS#:1338466-77-5
Solubility:Soluble in DMSO
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
Reference