Product Name: EPZ-015666
 CAT#: A-1516

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 Synonym:EPZ-015666,

EPZ-015666 Chemical Structure
EPZ-015666  chemical structure


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Biological Activity
EPZ015666 demonstrated potent killing of cancer cells in vitro and efficacy in animal models of MCL, with correlation to methyl mark inhibition. EPZ01566 is orally bioavailable and demonstrated dose-dependent inhibition of intracellular symmetric arginine di-methylation of SmD3, a PRMT5 substrate that plays a critical role in RNA processing. In pre-clinical studies, Z138 and Maver MCL cell lines were shown to be sensitive to EPZ015666, and in xenografts of these cell lines, the compound showed dose-dependent tumor growth inhibition.
Technical Data

Formula: C20H25N5O3
M.Wt: 383.44
CAS No: 1616391-65-1
Purity: >99%
Solubility: DMSO
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 2 years.
EPZ-015666 MSDS EPZ-015666 CoA

Reference







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