Product Name: EPZ-5676
 CAT#: A-1701

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 Synonym:EPZ5676

EPZ-5676 Chemical Structure
EPZ-5676 chemical structure


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IUPAC/Chemical name:
5'-[[cis-3-[2-(5-tert-Butyl-1H-benzimidazol-2- yl)ethyl]cyclobutyl](propan-2-yl)amino]-5'-deoxyadenosine

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Biological Activity
EPZ-5676 is a potent, selective and S-adenosyl methionine (SAM) competitive inhibitor of DOT1L methyltransferase (Ki = 80 pM), displaying 37,000-fold selectivity over all other methyltransferases tested. It inhibits H3K79 methylation and MLL-fusion target gene expression, and potently and selectively kills acute leukemia cell lines bearing MLL translocations.
Technical Data

CAS#: 1380288-87-8
Chemical Formula: C30H42N8O3• 0.5HCl
M.Wt.: 580.9
Chiral purity: 100%
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.

Reference







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