Product Name: FK-866
 CAT#: A-1303

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 Synonym:APO-866; APO866; FK866; Daporinad

FK-866 Chemical Structure
FK-866 chemical structure


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IUPAC/Chemical name: (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide.

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Biological Activity
FK866 is a potent inhibitor of NAD biosynthesis, and a specific inhibitor of NAMPT (Nicotinamide Phosphoribosyltransferase, visfatin, PBEF). NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAMPT also acts as a cytokine independent of its enzymatic activity, playing a major part in regulating immune responses.
Technical Data

Mol. Formula: C24H29N3O2
MW: 391.51
CAS#: 658084-64-1
Purity: >99%
FK-866 MSDS FK-866 CoA

Reference







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