Product Name: GDC-0084

Request GDC-0084

CAT#: A-6015


  Synonym:GDC-0084,

GDC-0084 Chemical Structure GDC-0084 chemical structure


IUPAC/Chemical name: 5-[8,9-dihydro-6,6-dimethyl-4-(4-morpholinyl)-6H-[1,4]oxazino[4,3-e]purin-2-yl]-2-Pyrimidinamine


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Biological Activity
A phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor GDC-0084 specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in the inhibition of both cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.
Technical Data
M.Wt:      382.42
Formula:     C18H22N8O2
CAS#: 1382979-44-3
Purity: >99% by HPLC
Storage Conditions: 0ºC to 4 ºC for short term or -20ºC for 3 years.

Reference