Product Name:  GDC-0623  Request GDC-0623
CAT#: A-1181    

Chemical Structure
GDC-0623 chemical structure

Price of GDC-0623


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Biological Activity

GDC-0623 is an orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.
Technical Data

Formula:    C16H14FIN4O3
M.Wt:     456.21
CAS#:    1168091-68-6
Purity:     >99%
Solubility : DMSO
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
Reference