Product Name: GDC-0810 (ARN-810)
 CAT#: A-9049

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 Synonym:GDC-0810 , GDC0810 (ARN-810)

GDC-0810 Chemical Structure
GDC-0810chemical structure


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IUPAC/Chemical name:

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Biological Activity
GDC-0810, also known as ARN-810, an orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity in tamoxifen-resistant breast cancer xenografts. GDC-0810 functions by binding to the estrogen receptor, inducing a conformational change resulting in the degradation of the receptor. GDC-0810 or ARN-810 demonstrates robust activity in models of tamoxifen-sensitive and tamoxifen-resistant breast cancer, and is currently in clinical trials in women with locally advanced or metastatic estrogen receptor-positive breast cancer.
Technical Data

Purity: >99%
CAS#:1365888-06-7
Chemical Formula:C26H20ClFN2O2
Molecular Weight:446.90
GDC-0810 MSDS GDC-0810 CoA

IUPAC/Chemical name: (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid
Canonical SMILES: O=C(O)/C=C/C1=CC=C(C=C1)/C(C2=CC3=C(NN=C3)C=C2)=C(CC)\C4=CC=C(C=C4Cl)F
Reference







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