Product Name: GDC-0917(CUDC-427)
 CAT#: A-1235

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 Synonym:GDC0917(CUDC427)

GDC-0917 Chemical Structure
GDC-0917 chemical structure


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IUPAC/Chemical name: (2S)-1-[(2S)-2-Cyclohexyl-2-[[(2S)-2- (methylamino)propanoyl]amino]acetyl]-N-(2-oxazol-2-yl-4-phenyl- thiazol-5-yl)pyrrolidine-2-carboxamide

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Biological Activity
GDC-0917 (CUDC-427) is an orally available, monovalent mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0917 (CUDC-427) binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2. This inhibits the activities of these IAPs and promotes the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains.
Technical Data

Mol. Formula: C29H36N6O4S
MW: 564.71
CAS#: 1446182-94-0
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
GDC-0917 MSDS GDC-0917 CoA

Reference







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