Product Name: GDC-0919

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CAT#: A-6083


  Synonym:GDC-0919,

GDC-0919 Chemical Structure GDC-0919 chemical structure


IUPAC/Chemical name: 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol


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Biological Activity
GDC-0919, also known as NLG919 and RG6078, is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential immunomodulating and antineoplastic activities. Upon administration, NLG919 targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against the IDO1-expressing tumor cells.
Technical Data
M.Wt:      282.38
Formula:     C18H22N2O
CAS#: 1402836-58-1
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.

Reference