Product Name: GDC-0994(GDC-0094, RG-7842)
 CAT#: A-1318

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GDC-0994 Chemical Structure
GDC-0994 chemical structure


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Biological Activity
GDC-0994 is a potent and selective Erk1/2 inhibitor.
An orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.
Technical Data

Formula:C21H18ClFN6O2
CAS#:1453848-26-4
M.Wt:440.87
Solubility:Soluble in DMSO
Purity: >99%
Storage Conditions: Room temperature, or -20ºC for 3 years.

Reference







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